2,4-Dichlorophenol → 2-(2,4-Dichlorophenoxy)-1-(4-methylphenyl)ethan-1-one

HRID 1730637Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[OH:9].[CH3:10][C:11]1[CH:20]=[CH:19][C:14]([C:15](=[O:18])[CH2:16]Cl)=[CH:13][CH:12]=1.C(=O)([O-])[O-].[K+].[K+]>>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[O:9][CH2:16][C:15]([C:14]1[CH:19]=[CH:20][C:11]([CH3:10])=[CH:12][CH:13]=1)=[O:18]

Participants

Reactant 3

HCID 84492,4-Dichlorophenol

HCID 11430Potassium Carbonate

HCID 2378052-Chloro-1-(4-methylphenyl)ethan-1-one

Product 1

HCID 214960082-(2,4-Dichlorophenoxy)-1-(4-methylphenyl)ethan-1-one

Procedure

Following the procedure given in Example 13a 2,4-dichlorophenol was interacted with an equimolar quantity of 4-methylphenacyl chloride in the presence of potassium carbonate to give w-(2,4-dichlorophenoxy)-p-methylacetophenone. Recrystallized from 2-ethoxyethanol, this product melted at 96.5-98.5° C.

Sources & evidence

ORD record: ord-dc1f084c2e974c2b8f20b74cf821a99a
Source dataset: uspto-grants-1976_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03993645

Reaction notes

Loading…