Hydrogen Peroxide → HCID 70361147, compound

HRID 1730696Notes

Reaction equation

HRID 1730696 reaction equation
[NH2:1][CH:2]1[C:13](=[O:14])[N:4]2[CH:5]([C:10]([OH:12])=[O:11])[C:6]([CH3:9])([CH3:8])[S:7][C@H:3]12.[OH:15]O.C(#N)C>O.O.O.[O-][W]([O-])(=O)=O.[Na+].[Na+]>[NH2:1][CH:2]1[C:13](=[O:14])[N:4]2[CH:5]([C:10]([OH:12])=[O:11])[C:6]([CH3:9])([CH3:8])[S:7](=[O:15])[C@H:3]12

Participants

6

Reactant 3

HCID 784Hydrogen PeroxideHCID 6342AcetonitrileHCID 12228589HCID 12228589, compound

Product 1

HCID 70361147HCID 70361147, compound

Reagents, catalysts & solvents 2

HCID 150191Sodium Tungstate DihydrateCatalystHCID 962WaterSolvent

Procedure

6-amino-2,2-dimethylpenam-3-carboxylic acid (1.06 g.) was suspended in water (6 cc), and sodium tungstate dihydrate (10 mg.) was added thereto. To the stirred mixture was added, dropwise, 30% hydrogen peroxide (0.8 cc) while cooling in an ice bath over a period of 20 minutes, and the mixture was stirred for 1 hour at the same temperature. To this mixture was added, dropwise, cooled acetonitrile (90 cc), and the precipitate was collected by filtration and dried under reduced pressure to yield a pale yellowish powder (0.85 g.) of 6-amino-2,2-dimethylpenam-3-carboxylic acid-1-oxide.

Workup

  1. additionTo the stirred mixture was added
  2. additionTo this mixture was added
  3. filtrationthe precipitate was collected by filtration
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-bb0a99ce882e4c6aa38eec5ca313b7fc
Source dataset
uspto-grants-1976_11
Patent number
US03993646

Reaction notes

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