Methanol → 2-Methyl-1-naphthol

HRID 1730715Notes

Reaction equation

[C:1]1([OH:11])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.[CH3:12]O>>[CH3:12][C:2]1[CH:3]=[CH:4][C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[C:1]=1[OH:11]

Participants

Reactant 2

HCID 887Methanol

HCID 70051-Naphthol

Product 1

HCID 240552-Methyl-1-naphthol

Procedure

α-Naphthol is methylated using methanol to form 2-methyl-1-naphthol over a catalyst bed of alumina. The reaction provides high selectivity to 2-methyl-1-naphthol. Alumina catalysts derived from alumina alkoxide hydrolysis are preferred.

Sources & evidence

ORD record: ord-6b7b23c1fac9409b8b1512454a5bcc95
Source dataset: uspto-grants-1976_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03993701

Reaction notes

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