Potassium Carbonate → HCID 54157981, compound

Participants

Reaction Steps

20 gm of the product thus obtained were reacted with 8.75 gm of thioglycolic acid methyl ester and 11.5 gm of potassium carbonate in 70 ml of dimethyl sulfoxide. From the obtained reaction product (oil, Rf -value: 0.4 on carrier 1 with cyclohexane/ethyl acetate = 2:1) [1-(2'-fluoro-4-biphenylyl)-2-hydroxy-ethylthio]acetic acid, m.p. 115°-117° C (from cyclohexane/ethyl acetate = 1:2, was obtained by hydrolysis. Preparation of end products of the formula I:

Provenance & Evidence