Potassium Carbonate → HCID 54157981, compound

HRID 1730740Notes

Reaction equation

HRID 1730740 reaction equation
[CH3:1][O:2][C:3](=[O:6])[CH2:4][SH:5].C(=O)([O-])[O-].[K+].[K+].[F:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[C:20]1[CH:25]=[CH:24][C:23]([CH:26](SCC(O)=O)[CH2:27][OH:28])=[CH:22][CH:21]=1.C1CCCCC1.C(OCC)(=O)C>CS(C)=O>[CH3:1][O:2][C:3](=[O:6])[CH2:4][S:5][CH:26]([C:23]1[CH:24]=[CH:25][C:20]([C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=2[F:13])=[CH:21][CH:22]=1)[CH2:27][OH:28]

Participants

6

Reactant 4

HCID 11430Potassium CarbonateHCID 16907Methyl ThioglycolateHCID 21496256HCID 21496256, compoundHCID 21867204Cyclohexane ethylacetate

Product 1

HCID 54157981HCID 54157981, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

20 gm of the product thus obtained were reacted with 8.75 gm of thioglycolic acid methyl ester and 11.5 gm of potassium carbonate in 70 ml of dimethyl sulfoxide. From the obtained reaction product (oil, Rf -value: 0.4 on carrier 1 with cyclohexane/ethyl acetate = 2:1) [1-(2'-fluoro-4-biphenylyl)-2-hydroxy-ethylthio]acetic acid, m.p. 115°-117° C (from cyclohexane/ethyl acetate = 1:2, was obtained by hydrolysis. Preparation of end products of the formula I:

Workup

  1. customwas obtained by hydrolysis
  2. customPreparation of end products of the formula I

Sources & evidence

ORD record
ord-1faf8c81288f499c867ad8384858a1c9
Source dataset
uspto-grants-1976_11
Patent number
US03993683

Reaction notes

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