Methyl chloroformate → HCID 53703941, compound

HRID 1730743Notes

Reaction equation

HRID 1730743 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:13]=[CH:12][C:11]([CH:14]([S:16]([CH2:18][C:19]([OH:21])=[O:20])=[O:17])[CH3:15])=[CH:10][CH:9]=1.[CH2:22](N(CC)CC)C.COC(Cl)=O>C(Cl)(Cl)Cl>[CH3:22][O:20][C:19](=[O:21])[CH2:18][S:16]([CH:14]([C:11]1[CH:12]=[CH:13][C:8]([C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[F:1])=[CH:9][CH:10]=1)[CH3:15])=[O:17]

Participants

5

Reactant 3

HCID 6586Methyl chloroformateHCID 8471TriethylamineHCID 20348737HCID 20348737, compound

Product 1

HCID 53703941HCID 53703941, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

306 mgm (1millimol) of [1-(2'-fluoro-4-biphenylyl)-ethylsulfinyl]-acetic acid and 0.15 ml of triethylamine were dissolved in 2 ml of chloroform, and 0.15 ml of chloroformic acid methyl ester was added to the solution at room temperature. After 30 minutes of standing, the mixture was washed with water, dried and evaporated, and the residue was recrystallized from 1 ml. of isopropanol. Yield: 200 mgm (62.5% of theory); m.p. 75°-78° C.

Workup

  1. washthe mixture was washed with water
  2. customdried
  3. customevaporated
  4. customthe residue was recrystallized from 1 ml

Sources & evidence

ORD record
ord-cedf71fe730d473a88aabda849609de1
Source dataset
uspto-grants-1976_11
Patent number
US03993683

Reaction notes

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