Hydrogen Peroxide → HCID 21496260, compound

HRID 1730753Notes

Reaction equation

HRID 1730753 reaction equation
[OH:1]O.[CH2:3]([S:5][CH2:6][C:7]([C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[F:21])=[CH:11][CH:10]=1)=[O:8])[CH3:4]>C(O)(=O)C>[CH2:3]([S:5]([CH2:6][C:7]([C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[F:21])=[CH:11][CH:10]=1)=[O:8])=[O:1])[CH3:4]

Participants

4

Reactant 2

HCID 784Hydrogen PeroxideHCID 21496283HCID 21496283, compound

Product 1

HCID 21496260HCID 21496260, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

12.8 ml of 30% hydrogen peroxide were added dropwise, while stirring, to a suspension of 16.3 gm (59.5 millimols) of ethyl-[2-(2'-fluoro-4-biphenylyl)-2-oxo-ethyl]-sulfide in 170 ml of glacial acetic acid at 15° C. A clear solution was obtained which was stirred for 1 hour at room temperature. The reaction product was precipitated with water and recrystallized from isopropanol. Yield: 11.6 gm (67% of theory); m.p. 91-93° C.

Workup

  1. customA clear solution was obtained which
  2. customThe reaction product was precipitated with water
  3. customrecrystallized from isopropanol

Sources & evidence

ORD record
ord-76b74316d46d475984c20c30662d11fa
Source dataset
uspto-grants-1976_11
Patent number
US03993683

Reaction notes

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