Hydrazine hydrate (1:1) → HCID 21496139, compound

HRID 1730769Notes

Reaction equation

HRID 1730769 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:21]2[C:25]([CH2:26][CH3:27])=NN=[C:22]2[CH2:28][N:29]2C(=O)C3=CC=CC=C3C2=O)=[C:6]([CH:20]=1)[C:7]([C:9]1[CH:14]=[CH:13][C:12]([S:15]([CH2:17][CH2:18][CH3:19])=O)=[CH:11][CH:10]=1)=O.[OH2:40].[NH2:41][NH2:42]>C(O)C>[F:1][C:2]1[CH:3]=[CH:4][C:5]2[N:21]3[C:25]([CH2:26][CH3:27])=[N:41][N:42]=[C:22]3[CH2:28][N:29]=[C:7]([C:9]3[CH:10]=[CH:11][C:12]([S:15]([CH2:17][CH2:18][CH3:19])=[O:40])=[CH:13][CH:14]=3)[C:6]=2[CH:20]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 21496152HCID 21496152, compound

Product 1

HCID 21496139HCID 21496139, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In the manner given in Example 5, 5-fluoro-4'-(propylsulfinyl)-2-[3-(phthalimidomethyl)-5-ethyl-4H-1,2,4-triazol-4-yl]benzophenone was heated in ethanol with hydrazine hydrate to give 8-fluoro-1-ethyl-6-[p-(propylsulfinyl)phenyl]-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record
ord-ebb928ef6c7e49898efc42a416976a17
Source dataset
uspto-grants-1976_11
Patent number
US03993660

Reaction notes

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