Hydrazine hydrate (1:1) → HCID 21496159, compound

HRID 1730770Notes

Reaction equation

HRID 1730770 reaction equation
[CH3:1][S:2][C:3]1[CH:4]=[CH:5][C:6]([N:18]2[C:22]([CH3:23])=[N:21][N:20]=[C:19]2[CH2:24][N:25]2C(=O)C3=CC=CC=C3C2=O)=[C:7]([CH:17]=1)[C:8]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[Cl:16])=O.O.NN>C(O)C>[CH3:1][S:2][C:3]1[CH:4]=[CH:5][C:6]2[N:18]3[C:22]([CH3:23])=[N:21][N:20]=[C:19]3[CH2:24][N:25]=[C:8]([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=3[Cl:16])[C:7]=2[CH:17]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 21496131HCID 21496131, compound

Product 1

HCID 21496159HCID 21496159, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In the manner given in Example 5, 5-methylthio-2'-chloro-2-[3-(phthalimidomethyl)-5-methyl-4H-1,2,4-triazol-4-yl]benzophenone was heated in ethanol with hydrazine hydrate to give 8-methylthio-1-methyl-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record
ord-b70f8c9dc3f648f5956e3d5ebbcef3cf
Source dataset
uspto-grants-1976_11
Patent number
US03993660

Reaction notes

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