Dimethylamine → Benzophenone

HRID 1730777Notes

Reaction equation

HRID 1730777 reaction equation
Cl[C:2]1[CH:3]=[CH:4][C:5](N2C(CO)=NN=C2C)=[C:6]([CH:15]=1)[C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:8].CS(Cl)(=O)=O.CNC.[I-].[K+]>C(N(CC)CC)C>[C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)(=[O:8])[C:6]1[CH:15]=[CH:2][CH:3]=[CH:4][CH:5]=1

Participants

6

Reactant 4

HCID 674DimethylamineHCID 4875Potassium IodideHCID 31297Methanesulfonyl chlorideHCID 170010(5-Chloro-2-(3-(hydroxymethyl)-5-methyl-4H-1,2,4-triazol-4-yl)phenyl)phenylmethanone

Product 1

HCID 3102Benzophenone

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

In the manner given in Example 21, 5-chloro-[3-methyl-5-(hydroxymethyl)-4H-1,2,4-triazol-4-yl]benzophenone was reacted with methanesulfonyl chloride in the presence of triethylamine and the resulting solution, treated with gaseous dimethylamine in the presence of potassium iodide, to give 5-chloro-2-[3-methyl-5-(dimethylamino)methyl]-4H-1,2,4-triazol-4-yl]benzophenone of melting point 171°-172°.

Sources & evidence

ORD record
ord-36dd8595573c43e6bd2af3e5ff75ea46
Source dataset
uspto-grants-1976_11
Patent number
US03993660

Reaction notes

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