Tert-Butyl hypochlorite → HCID 70636150, compound

HRID 1730859Notes

Reaction equation

HRID 1730859 reaction equation
[CH3:1][O:2][CH2:3][C:4]1[CH2:5][S:6][C@@H:7]2[CH:27]([NH:28][C:29](=[O:36])[CH2:30][C:31]3[S:32][CH:33]=[CH:34][CH:35]=3)[C:26](=[O:37])[N:8]2[C:9]=1[C:10]([O:12][CH:13]([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[O:11].C[Li].Cl[O:41][C:42](C)(C)C>CO>[CH3:1][O:2][CH2:3][C:4]1[CH2:5][S:6][C@@H:7]2[C:27]([O:41][CH3:42])([NH:28][C:29](=[O:36])[CH2:30][C:31]3[S:32][CH:33]=[CH:34][CH:35]=3)[C:26](=[O:37])[N:8]2[C:9]=1[C:10]([O:12][CH:13]([C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)=[O:11]

Participants

5

Reactant 3

HCID 521297Tert-Butyl hypochloriteHCID 70635455HCID 70635455, compoundHCID 178418348HCID 178418348, compound

Product 1

HCID 70636150HCID 70636150, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In accordance with the procedures described by Example 1, benzhydryl 3-methoxymethyl-7-[2-(2-thienyl)acetamido]-3-cephem-4-carboxylate was reacted at a temperature of -80° C. with methyl lithium in the presence of methanol and t-butyl hypochlorite to provide benzhydryl 3-methoxymethyl-7-methoxy-7-[2-(2-thienyl)acetamido]-3-cephem-4-carboxylate.

Sources & evidence

ORD record
ord-33ddf1ee8a5249d489b2ab2800dd2232
Source dataset
uspto-grants-1976_11
Patent number
US03994885

Reaction notes

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