1-Bromopropane → 6-(Butylamino)-2-propyl[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one

HRID 1730878Notes

Reaction equation

HRID 1730878 reaction equation
[CH2:1]([NH:5][C:6]1[CH:7]=[CH:8][C:9]2[N:10]([C:12](=[O:15])[NH:13][N:14]=2)[N:11]=1)[CH2:2][CH2:3][CH3:4].[CH2:16](Br)[CH2:17][CH3:18]>>[CH2:1]([NH:5][C:6]1[CH:7]=[CH:8][C:9]2[N:10]([C:12](=[O:15])[N:13]([CH2:16][CH2:17][CH3:18])[N:14]=2)[N:11]=1)[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 78401-BromopropaneHCID 214943096-(Butylamino)[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one

Product 1

HCID 214943186-(Butylamino)-2-propyl[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-oneYield 86%

Procedure

By reacting the product of Example 3 with propyl bromide according to the procedure of Example 4, 6-n-butylamino-2-propyl-1,2,4-triazolo[4,3-b]pyridazin-3(2H)-one is obtained, yield 86%, m.p. 183°-185° (ethyl acetate with some drops of absolute ethanol). The hydrochloride is obtained by treatment with ethanolic HCl.

Sources & evidence

ORD record
ord-9051f45b06ad4561a92b33a4f602c869
Source dataset
uspto-grants-1976_11
Patent number
US03994898

Reaction notes

Loading…