Hydrochloric Acid → HCID 131710541, compound

HRID 1730915Notes

Reaction equation

HRID 1730915 reaction equation
[CH3:1][N:2]([CH3:24])[CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[NH:13][C:12](=[O:17])[CH2:11][CH:10]2[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.[ClH:25].CCOCC>C(O)C>[ClH:25].[CH3:24][N:2]([CH3:1])[CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[NH:13][C:12](=[O:17])[CH2:11][CH:10]2[C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 214943276-[3-(Dimethylamino)propoxy]-4-phenyl-3,4-dihydroquinolin-2(1H)-one

Product 1

HCID 131710541HCID 131710541, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 6-[3-(dimethylamino)propoxy]-3,4-dihydro-4-phenyl-2 (1H)-quinolinone (16.3g) in 30 ml of warm ethanol is stirred and treated dropwise with one equivalent of ethanolic hydrogen chloride. At 25° C, an equal volume of ether is added and the solution is seeded and cooled to give 13.3g of crystals. Crystallization from 200 ml of acetonitrile yields 12.0g of the title compound, melting point 182°-184° C.

Workup

  1. temperaturecooled

Sources & evidence

ORD record
ord-e1f654093f704baebcb398c9b537aa13
Source dataset
uspto-grants-1976_11
Patent number
US03994900

Reaction notes

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