5-Chloro-3-phenyl-1H-indazole → 1-Dimethylaminoethyl-3-phenyl-5-chloroindazole hydrochloride

HRID 1730923Notes

Reaction equation

HRID 1730923 reaction equation
[C:1]1([C:7]2[C:15]3[C:10](=[CH:11][CH:12]=[C:13]([Cl:16])[CH:14]=3)[NH:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[CH3:18][N:19]([CH2:21][CH2:22]Cl)[CH3:20]>>[ClH:16].[CH3:18][N:19]([CH3:20])[CH:21]([C:14]1[C:13]([Cl:16])=[CH:12][CH:11]=[C:10]2[C:15]=1[C:7]([C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)=[N:8][NH:9]2)[CH3:22]

Participants

3

Reactant 2

HCID 6151185-Chloro-3-phenyl-1H-indazoleHCID 11636816N,N-Dimethylaminoethyl chloride hydrochloride

Product 1

HCID 681414761-Dimethylaminoethyl-3-phenyl-5-chloroindazole hydrochlorideYield 104.2%

Procedure

By the procedure similar to that described in Example 1, 3-phenyl-5-chloroindazole (4.57 g) and dimethylaminoethyl chloride hydrochloride (4.32 g) were treated to obtain 3.5 g of 1-dimethylaminoethyl-3-phenyl-5-chloroindazole hydrochloride (m.p. 200°-201° C).

Workup

  1. additionwere treated

Sources & evidence

ORD record
ord-e0b14f037dec4fb08b4d46ba342c6f5e
Source dataset
uspto-grants-1976_11
Patent number
US03994890

Reaction notes

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