反应详情

3-Phenyl-5-chloroindazole (2.29 g), paraformaldehyde (0.35 g), morpholine (1.91 g) and 1N aqeous sodium hydroxide solution (1 ml) were added to 40 ml of ethanol and the mixture was allowed to react under reflux. The reaction mixture was concentrated and then the residue was dissolved in chloroform, washed with water, dried over sodium sulfate and concentrated. The residue was treated with column chromatography to obtain 1.7 g of 1-morpholinomethyl-3-phenyl-5-chloroindazole having a melting point of between 155°-156° C after recrystallization from methanol.

1. customto react
2. temperatureunder reflux
3. concentrationThe reaction mixture was concentrated
4. dissolutionthe residue was dissolved in chloroform
5. washwashed with water
6. dry with materialdried over sodium sulfate
7. concentrationconcentrated
8. additionThe residue was treated with column chromatography