Formaldehyde → HCID 68140987, compound

HRID 1730939Notes

Reaction equation

HRID 1730939 reaction equation
[C:1]1([C:7]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[NH:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C=O.[C:18]1([N:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)C=CC=CC=1>>[C:1]1([N:9]2[C:10]3[C:15](=[C:14]([CH2:18][N:24]4[CH2:25][CH2:26][NH:27][CH2:28][CH2:29]4)[CH:13]=[CH:12][CH:11]=3)[C:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)=[N:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 3

HCID 712FormaldehydeHCID 70961-PhenylpiperazineHCID 3003853-phenyl-1H-indazole

Product 1

HCID 68140987HCID 68140987, compoundYield 155.8%

Procedure

By the procedure similar to that described in Example 19, 3-phenylindazole (2.91 g), paraformaldehyde (0.50 g) and N-phenylpiperazine (4.87 g) were treated to obtain 4.3 g of 1-N-phenylpiperazinomethyl-3-phenylindazole having a melting point between 109°-110° C after recrystallization from ethanol.

Workup

  1. additionwere treated

Sources & evidence

ORD record
ord-6d2af97d81724effaeaaeaf6afe700d4
Source dataset
uspto-grants-1976_11
Patent number
US03994890

Reaction notes

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