1-Phenylpiperazine → HCID 68140870, compound

HRID 1730945Notes

Reaction equation

HRID 1730945 reaction equation
[C:1]1([N:7]2[C:15]3[C:10](=[C:11]([CH2:17][CH2:18][C:19](N4CCNCC4)=O)[C:12]([CH3:16])=[CH:13][CH:14]=3)[C:9]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)=[N:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.OC(C(C1C(C)=CC=C2C=1C(C1C=CC=CC=1)=NN2)C)=O.C([Cl:59])(=O)OCC.C1([N:66]2[CH2:71][CH2:70][NH:69][CH2:68][CH2:67]2)C=CC=CC=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[ClH:59].[C:1]1([N:7]2[C:15]3[C:10](=[C:11]([CH2:17][CH2:18][CH3:19])[C:12]([CH3:16])=[C:13]([N:66]4[CH2:71][CH2:70][NH:69][CH2:68][CH2:67]4)[CH:14]=3)[C:9]([C:27]3[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=3)=[N:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

6

Reactant 5

HCID 70961-PhenylpiperazineHCID 10928Ethyl chloroformateHCID 21226445Aluminium lithium hydrideHCID 68139588HCID 68139588, compoundHCID 68139760HCID 68139760, compound

Product 1

HCID 68140870HCID 68140870, compound

Procedure

Oily 1-N-phenylpiperazinocarbonylethyl-3-phenyl-5-methylindazole (4.0 g) which had been prepared by reacting in order 1-hydroxycarbonylethyl-3-phenyl-5-methylindazole with ethyl chlorocarbonate and N-phenyl-piperazine was treated with the use of lithium aluminum hydride (1.2 g) by the procedure similar to that described in Example 27 to obtain 6.1 g of 1-N-phenylpiperazino-propyl-3-phenyl-5-methylindazole hydrochloride having a melting point between 195°-200° C after recrystallization from ethanol-ether.

Sources & evidence

ORD record
ord-3ed3288bb27542d2b399cca86d3aa19e
Source dataset
uspto-grants-1976_11
Patent number
US03994890

Reaction notes

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