Aluminium lithium hydride → HCID 68139879, compound

HRID 1730946Notes

Reaction equation

HRID 1730946 reaction equation
C(C([C:6]1[C:14]([Cl:15])=[CH:13][CH:12]=[C:11]2[C:7]=1[C:8]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[N:9][NH:10]2)C)(=O)N.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[ClH:15].[NH2:9][CH:8]([C:6]1[C:14]([Cl:15])=[CH:13][CH:12]=[C:11]2[C:7]=1[C:8]([C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1)=[N:9][NH:10]2)[CH2:7][CH3:6]

Participants

3

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 86734223HCID 86734223, compound

Product 1

HCID 68139879HCID 68139879, compoundYield 74.4%

Procedure

By the procedure similar to that described in Example 27, 1-carbamoylethyl-3-phenyl-5-chloroindazole (m.p. 156°-157° C) (5.0 g) was treated with the use of lithium aluminum hydride (1.5 g) to obtain 2.0 g of 1-aminopropyl-3-phenyl-5-chloroindazole hydrochloride having a melting point between 163°-164° C after recrystallization from ethanol-ether.

Sources & evidence

ORD record
ord-ec084b82332d43f680f4b102a9557e94
Source dataset
uspto-grants-1976_11
Patent number
US03994890

Reaction notes

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