Triethylamine → HCID 21494439, compound

HRID 1730957Notes

Reaction equation

HRID 1730957 reaction equation
[CH2:1]([C:8]1[N:12]=[C:11]([OH:13])[O:10][N:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:14]([N:17]=[C:18]=[O:19])[CH2:15][CH3:16].C(N(CC)CC)C>O1CCOCC1>[CH2:1]([C:8]1[N:12]([C:18](=[O:19])[NH:17][CH2:14][CH2:15][CH3:16])[C:11](=[O:13])[O:10][N:9]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 61033Propyl isocyanateHCID 178517637HCID 178517637, compound

Product 1

HCID 21494439HCID 21494439, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

8.8 parts of 3-benzyl-5-hydroxy-1,2,4-oxadiazole is stirred for 1 hour at room temperature with 4.3 parts of n-propyl isocyanate and 2 parts of triethylamine in 50 parts of dioxane. The reaction mixture is then poured into ice water, and the precipitated solid is suction filtered and recrystallized from alcohol. There is obtained 8.5 parts (65% of theory) of the desired product; m.p.: 74° C.

Workup

  1. filtrationfiltered
  2. customrecrystallized from alcohol

Sources & evidence

ORD record
ord-a358a12041974171bc07feffb2c7d8be
Source dataset
uspto-grants-1976_11
Patent number
US03994909

Reaction notes

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