反应详情

A mixture of 4,5,6,7-tetrahydro-7-oxobenzo[b]thien-4-ylisothiocyanate (5.0 g) and methylene chloride (100 ml) is stirred and a saturated solution of methylamine in ethanol (15 ml ethanol saturated with methylamine) added. The mixture is stirred for 15 hours then heated at reflux for 2 hours, cooled and evaporated to dryness in vacuo. The residue is triturated with water, the title thiourea collected and dried.

1. stirringThe mixture is stirred for 15 hours
2. temperaturethen heated
3. temperatureat reflux for 2 hours
4. temperaturecooled
5. customevaporated to dryness in vacuo
6. customThe residue is triturated with water
7. customthe title thiourea collected
8. customdried