反应详情

Alternatively, N-t-Butoxycarbonyl-2-phenoxyglycine n-butyl ester was prepared by heating a mixture of 1.5 g. (0.005 mol.) of N-t-butoxycarbonyl-2-acetoxylglycine n-butyl ester and 0.5 g. (0.005 mol.) of phenol at 150° for 1 hour. The residue was dissolved in ethyl acetate and the resulting solution was washed with cold 10% aqueous sodium hydroxide, dried (MgSO4) and concentrated to give the title compound.

1. customAlternatively, N-t-Butoxycarbonyl-2-phenoxyglycine n-butyl ester was prepared
2. temperatureby heating
3. additiona mixture of 1.5 g
4. washthe resulting solution was washed with cold 10% aqueous sodium hydroxide
5. dry with materialdried (MgSO4)
6. concentrationconcentrated