Hydrochloric Acid → HCID 178513106, compound

HRID 1731056Notes

Reaction equation

HRID 1731056 reaction equation
[C:1]([NH:4][C:5]([NH:7][N+]([O-])=O)=[O:6])(=[NH:3])[NH2:2].N[CH2:12][C:13]([OH:15])=[O:14].Cl>O>[C:1]([NH:4][C:5](=[O:6])[NH:7][CH2:12][C:13]([OH:15])=[O:14])(=[NH:3])[NH2:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 750GlycineHCID 178513107HCID 178513107, compound

Product 1

HCID 178513106HCID 178513106, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
10 °C

Procedure

The pH of a mixture of 29.4 g (0.2 mole) of N-guanyl-N'-nitrourea and 7.5 g. (0.1 mole) of glycine in 200 ml. of water is adjusted to 6.0 and the resulting solution heated to reflux. During the 2 hrs. of reflux (95°-97° C.) the pH of the reaction is maintained between 6 and 7 by the addition of 10% hydrochloric acid. The reaction, after 2 hours reflux, is cooled to 10° C. and the pH adjusted to 6.9. The precipitate is filtered, washed with 500 ml. of water and dried to give 14 g. of the desired intermediate, m.p. 202° C. (dec.).

Workup

  1. temperaturethe resulting solution heated to reflux
  2. customDuring the 2 hrs
  3. temperatureof reflux (95°-97° C.) the pH of the reaction
  4. customThe reaction
  5. temperatureafter 2 hours reflux
  6. filtrationThe precipitate is filtered
  7. washwashed with 500 ml
  8. dry with materialof water and dried
  9. customto give 14 g

Sources & evidence

ORD record
ord-c3806f46e0974efc8538bf617fc4a93f
Source dataset
uspto-grants-1976_11
Patent number
US03994965

Reaction notes

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