Formaldehyde → HCID 21494821, compound

HRID 1731076Notes

Reaction equation

HRID 1731076 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[C:12]([CH3:15])=[N:13][N:14]=[C:10]3[CH2:9][N:8]=[C:7]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=3)[C:6]=2[CH:22]=1.[CH2:23]=[O:24]>C1(C)C(C)=CC=CC=1>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[C:12]([CH2:15][CH2:23][OH:24])=[N:13][N:14]=[C:10]3[CH2:9][N:8]=[C:7]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=3)[C:6]=2[CH:22]=1

Participants

4

Reactant 2

HCID 712FormaldehydeHCID 12562545Pyrazolam

Product 1

HCID 21494821HCID 21494821, compound

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

In the manner given in Example 1, 8bromo-1-methyl-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine in xylene is heated in an oil bath at 105°-110° C. with formaldehyde gas bubbling through the solution to give 8-bromo-1-(2-hydroxyethyl)-6-(2-pyridyl)-4H-s-triazolo-[4,3-a][1,4]benzodiazepine.

Workup

  1. custombubbling through the solution

Sources & evidence

ORD record
ord-20c73ee231a2454b9087e138bacd48d3
Source dataset
uspto-grants-1976_11
Patent number
US03994941

Reaction notes

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