Formaldehyde → HCID 21494817, compound

HRID 1731080Notes

Reaction equation

HRID 1731080 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[N:12]2[C:19]([CH3:22])=[N:20][N:21]=[C:11]2[CH2:10][N:9]=1.[CH2:23]=[O:24]>C1(C)C(C)=CC=CC=1>[OH:24][CH2:23][CH2:22][C:19]1[N:12]2[C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[C:8]([C:3]3[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=3[Cl:1])=[N:9][CH2:10][C:11]2=[N:21][N:20]=1

Participants

4

Reactant 2

HCID 712FormaldehydeHCID 21680194HCID 21680194, compound

Product 1

HCID 21494817HCID 21494817, compound

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

In the manner given in Example 1, 6-(o-chlorophenyl)-1-methyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine in xylene is heated with repeated additions of paraformaldehyde in an oil bath to give 1-(2-hydroxyethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record
ord-97660c70460f4980a93a26e8468c4b4e
Source dataset
uspto-grants-1976_11
Patent number
US03994941

Reaction notes

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