Hydrazine hydrate (1:1) → HCID 21494834, compound

HRID 1731087Notes

Reaction equation

HRID 1731087 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[C:12]([CH2:15][CH2:16][N:17]4C(=O)C5=CC=CC=C5C4=O)=[N:13][N:14]=[C:10]3[CH2:9][N:8]=[C:7]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)[C:6]=2[CH:34]=1.O.NN>C(O)C>[NH2:17][CH2:16][CH2:15][C:12]1[N:11]2[C:5]3[CH:4]=[CH:3][C:2]([F:1])=[CH:34][C:6]=3[C:7]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)=[N:8][CH2:9][C:10]2=[N:14][N:13]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 21494836HCID 21494836, compound

Product 1

HCID 21494834HCID 21494834, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In the manner given in Example 21, a solution of 8-fluoro-6-phenyl-1-(2-phthalimidoethyl)-4H-s-triazolo-[4,3-a][1,4]benzodiazepine in ethanol is heated with hydrazine hydrate to give 1-(2-aminoethyl)-8-fluoro-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine

Sources & evidence

ORD record
ord-3875b74bcf6b44ed93f38f1109e737b9
Source dataset
uspto-grants-1976_11
Patent number
US03994941

Reaction notes

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