Hydrazine hydrate (1:1) → HCID 21494766, compound

Participants

Reaction Steps

In the manner given in Example 1C, 5-fluoro-2-[3-[2-(dimethylamino)ethyl]-5-(phthalimidomethyl)-4H-1,2,4-triazol-4-yl]benzophenone in ethanol is refluxed with hydrazine hydrate to give 1-[2-(dimethylamino)ethyl]-8-fluoro-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine. This compound is converted to its hydrobromide by treating it with hydrogen bromide gas in ether.

Provenance & Evidence