Hydrazine hydrate (1:1) → HCID 21494766, compound

HRID 1731109Notes

Reaction equation

HRID 1731109 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:16]2[C:20]([CH2:21][N:22]3[C:26](=O)[C:25]4=[CH:28][CH:29]=[CH:30][CH:31]=[C:24]4C3=O)=[N:19][N:18]=[C:17]2[CH2:33][CH2:34][N:35]([CH3:37])[CH3:36])=[C:6]([CH:15]=1)C(C1C=CC=CC=1)=O.O.NN>C(O)C>[CH3:36][N:35]([CH3:37])[CH2:34][CH2:33][C:17]1[N:16]2[C:5]3[CH:6]=[CH:15][C:2]([F:1])=[CH:3][C:4]=3[C:26]([C:25]3[CH:24]=[CH:31][CH:30]=[CH:29][CH:28]=3)=[N:22][CH2:21][C:20]2=[N:19][N:18]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 21494755HCID 21494755, compound

Product 1

HCID 21494766HCID 21494766, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In the manner given in Example 1C, 5-fluoro-2-[3-[2-(dimethylamino)ethyl]-5-(phthalimidomethyl)-4H-1,2,4-triazol-4-yl]benzophenone in ethanol is refluxed with hydrazine hydrate to give 1-[2-(dimethylamino)ethyl]-8-fluoro-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine. This compound is converted to its hydrobromide by treating it with hydrogen bromide gas in ether.

Sources & evidence

ORD record
ord-5472fc4e2fa4424b9ddd2cf6a93df618
Source dataset
uspto-grants-1976_11
Patent number
US03994940

Reaction notes

Loading…