Hydrazine hydrate (1:1) → HCID 12612418, compound

HRID 1731111Notes

Reaction equation

HRID 1731111 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=O)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[N:15]1[C:19]([CH2:20][N:21]2C(=O)C3=CC=CC=C3C2=O)=[N:18][N:17]=[C:16]1[CH2:32][CH2:33][N:34]([CH3:36])[CH3:35].O.NN>C(O)C>[CH3:35][N:34]([CH3:36])[CH2:33][CH2:32][C:16]1[N:15]2[C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=3[C:8]([C:3]3[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=3[Cl:1])=[N:21][CH2:20][C:19]2=[N:18][N:17]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 21494728HCID 21494728, compound

Product 1

HCID 12612418HCID 12612418, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In the manner given in Example 1C, 2'-chloro-2-[3-[2-(dimethylamino)ethyl]-5-(phthalimidomethyl)-4H-1,2,4-triazol-4-yl]benzophenone in ethanol is refluxed with hydrazine hydrate to give 1-[2-(dimethylamino)ethyl]-6-(o-chlorophenyl)-4H-s-triazolo-[4,3-a][1,4]benzodiazepine. Its methanesulfamate is obtained by treatment with methanesulfamic acid in ether.

Sources & evidence

ORD record
ord-7825ca26a55b4b92b696365d099d25a4
Source dataset
uspto-grants-1976_11
Patent number
US03994940

Reaction notes

Loading…