Hydrazine hydrate (1:1) → HCID 20368155, compound

HRID 1731113Notes

Reaction equation

HRID 1731113 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:18]2[C:22]([CH2:23][N:24]3C(=O)C4=CC=CC=C4C3=O)=[N:21][N:20]=[C:19]2[CH2:35][CH2:36][N:37]([CH3:39])[CH3:38])=[C:6]([CH:17]=1)[C:7]([C:9]1[C:14]([F:15])=[CH:13][CH:12]=[CH:11][C:10]=1[F:16])=O.O.NN>C(O)C>[CH3:39][N:37]([CH3:38])[CH2:36][CH2:35][C:19]1[N:18]2[C:5]3[CH:4]=[CH:3][C:2]([Cl:1])=[CH:17][C:6]=3[C:7]([C:9]3[C:10]([F:16])=[CH:11][CH:12]=[CH:13][C:14]=3[F:15])=[N:24][CH2:23][C:22]2=[N:21][N:20]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 21494777HCID 21494777, compound

Product 1

HCID 20368155HCID 20368155, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In the manner given in Example 1C, 5-chloro-2',6'-difluoro-2-[3-[2-(dimethylamino)ethyl]-5-(phthalimidomethyl)-4H-1,2,4-triazol-4-yl]benzophenone in ethanol is refluxed with hydrazine hydrate to give 1-[2-(dimethylamino)ethyl]-8-chloro-6-(2,6-difluorophenyl)-4H-s-triazolo-[4,3-a][1,4]benzodiazepine. This compound is converted to its hydrochloride by treating it with ethereal hydrogen chloride.

Sources & evidence

ORD record
ord-b3d2c98a3fba43cb8ffc2d71bde88aee
Source dataset
uspto-grants-1976_11
Patent number
US03994940

Reaction notes

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