4-Phenylpiperidine → 4-Phenyl-1-piperidinepropanamine, hydrochloride

HRID 1731131Notes

Reaction equation

[C:1]1([CH:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl:13][CH:14]([CH3:17])[C:15]#[N:16]>>[ClH:13].[C:1]1([CH:7]2[CH2:8][CH2:9][N:10]([CH2:17][CH2:14][CH2:15][NH2:16])[CH2:11][CH2:12]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

Reactant 2

HCID 698734-Phenylpiperidine

HCID 5192252-Chloropropionitrile

Product 1

HCID 1317105484-Phenyl-1-piperidinepropanamine, hydrochloride

Procedure

The above compound is prepared as described in Example 1A and B except that 4-phenylpiperidine is employed in place of 4-phenyl-1,2,3,6-tetrahydropyridine and chloropropionitrile is used in place of 4-bromobutyronitrile.

Workup

customThe above compound is prepared

Sources & evidence

ORD record: ord-b6b97fb041cb437085afaba4dd6e4313
Source dataset: uspto-grants-1976_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03995045

Reaction notes

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