2-Pyridinemethanamine → HCID 54262084, compound

HRID 1731133Notes

Reaction equation

HRID 1731133 reaction equation
CO[C:3](=[O:18])[C:4]1[CH:9]=[CH:8][C:7]([C:10]([F:13])([F:12])[F:11])=[CH:6][C:5]=1[C:14]([F:17])([F:16])[F:15].[NH2:19][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][N:22]=1>>[N:22]1[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=1[CH2:20][NH:19][C:3](=[O:18])[C:4]1[CH:9]=[CH:8][C:7]([C:10]([F:11])([F:12])[F:13])=[CH:6][C:5]=1[C:14]([F:15])([F:16])[F:17]

Participants

3

Reactant 2

HCID 195092-PyridinemethanamineHCID 18925643Methyl 2,4-bis(trifluoromethyl)benzoate

Product 1

HCID 54262084HCID 54262084, compoundYield 64%

Procedure

5.4 g of 2,4-bis(trifluoromethyl)benzoic acid methyl ester and 2.5 g of 2-aminomethylpyridine were heated to 160°-180° C for 6 hours. After cooling, the product was recrystallized from toluene. 4.2 g (64% of theory) of N-(pyrid-2-ylmethyl)-2,4-bis(trifluoromethyl)benzoic acid amide of melting point 112°-113° C were thus obtained.

Workup

  1. temperatureAfter cooling
  2. customthe product was recrystallized from toluene

Sources & evidence

ORD record
ord-521f76244f714722aac12e4e62bb6a2b
Source dataset
uspto-grants-1976_11
Patent number
US03995044

Reaction notes

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