Boron trifluoride etherate → 3-(1-Methyl-1,3,4,9-tetrahydroindeno[2,1-c]pyran-1-yl)propanoic acid

HRID 1731137Notes

Reaction equation

HRID 1731137 reaction equation
[CH2:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH2:10][CH2:11][OH:12])=[CH:2]1.[C:13]([OH:20])(=[O:19])[CH2:14][CH2:15][C:16]([CH3:18])=O.B(F)(F)F.CCOCC>C1C=CC=CC=1>[CH3:18][C:16]1([CH2:15][CH2:14][C:13]([OH:20])=[O:19])[C:2]2[CH2:1][C:9]3[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=3[C:3]=2[CH2:10][CH2:11][O:12]1

Participants

5

Reactant 3

HCID 8000Boron trifluoride etherateHCID 11579Levulinic AcidHCID 113556481H-Indene-3-ethanol

Product 1

HCID 214953483-(1-Methyl-1,3,4,9-tetrahydroindeno[2,1-c]pyran-1-yl)propanoic acid

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

A mixture of indene-3-ethanol (15 g), dry benzene (300 ml), levulinic acid (22.6 g), boron trifluoride etherate (3 ml) and hydrated alkali-aluminum silicate (Molecular Sieves No. 4) is stirred at ambient temperature for 2 hr.

Sources & evidence

ORD record
ord-2cfa03dbbfb643fc9e705ab516786625
Source dataset
uspto-grants-1976_11
Patent number
US03995052

Reaction notes

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