HRID1731229

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID14991594

未命名化合物

结构：O=C(ON1C(=O)CCC1=O)[C@H](CSC(c1ccccc1)(c1ccccc1)c1ccccc1)NC(c1ccccc1)(c1ccccc1)c1ccccc1

HCID88804794

未命名化合物

PRODUCTS

生成物

结构：COC(=O)[C@H](CSCNC(C)=O)NC(=O)[C@H](CSC(c1ccccc1)(c1ccccc1)c1ccccc1)NC(c1ccccc1)(c1ccccc1)c1ccccc1

HCID131710552

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6212

Chloroform

CHCl3

2 次

PROCEDURE

实验过程

7.0 g of Trt-Cys(Trt)-OSu and 2.0 g of H-Cys(Acm)-OMe in 50 ml of chloroform are left to stand for 20 hours at room temperature. The solution is then diluted with 100 ml of chloroform and washed with 1 N citric acid, 1 N sodium bicarbonate and water, dried over sodium sulphate and evaporated. The residue is recrystallised from ethyl acetate-ether. Melting point 197°-198°C.

WORKUP

后处理

washwashed with 1 N citric acid, 1 N sodium bicarbonate and water
dry with materialdried over sodium sulphate
customevaporated
customThe residue is recrystallised from ethyl acetate-ether

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-63edf12cdeb245f9a098ec0ef469e8fa
来源数据集: uspto-grants-1976_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US03994871
来源说明: uspto-grants-1976_11

反应 SMILES

[NH:1]([C:34]([C:47]1[CH:52]=[CH:51][CH:50]=[CH:49][CH:48]=1)([C:41]1[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=1)[C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1)[C@H:2]([C:24](ON1C(=O)CCC1=O)=[O:25])[CH2:3][S:4][C:5]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.[NH2:53][C@H:54]([C:62]([O:64][CH3:65])=[O:63])[CH2:55][S:56][CH2:57][NH:58][C:59]([CH3:61])=[O:60]>C(Cl)(Cl)Cl>[NH:1]([C:34]([C:47]1[CH:52]=[CH:51][CH:50]=[CH:49][CH:48]=1)([C:35]1[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=1)[C:41]1[CH:42]=[CH:43][CH:44]=[CH:45][CH:46]=1)[C@H:2]([C:24]([NH:53][C@H:54]([C:62]([O:64][CH3:65])=[O:63])[CH2:55][S:56][CH2:57][NH:58][C:59]([CH3:61])=[O:60])=[O:25])[CH2:3][S:4][C:5]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1