Methyl (2R)-2-amino-3-[(acetamidomethyl)sulfanyl]propanoate → Trt-Cys(Trt)-Cys(Acm)-OMe

Participants

Reaction Steps

7.0 g of Trt-Cys(Trt)-OSu and 2.0 g of H-Cys(Acm)-OMe in 50 ml of chloroform are left to stand for 20 hours at room temperature. The solution is then diluted with 100 ml of chloroform and washed with 1 N citric acid, 1 N sodium bicarbonate and water, dried over sodium sulphate and evaporated. The residue is recrystallised from ethyl acetate-ether. Melting point 197°-198°C.

Provenance & Evidence