Z-Thr(But)-Ser(But)-OMe → H-Thr(But)-Ser(But)-OMe

HRID 1731232Notes

Reaction equation

HRID 1731232 reaction equation
[NH:1](C(OCC1C=CC=CC=1)=O)[C@H:2]([C:10]([NH:12][C@H:13]([C:20]([O:22][CH3:23])=[O:21])[CH2:14][O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:11])[C@@H:3]([CH3:9])[O:4][C:5]([CH3:8])([CH3:7])[CH3:6]>C(OCC)(=O)C.[Pd]>[NH2:1][C@H:2]([C:10]([NH:12][C@H:13]([C:20]([O:22][CH3:23])=[O:21])[CH2:14][O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:11])[C@@H:3]([CH3:9])[O:4][C:5]([CH3:8])([CH3:7])[CH3:6]

Participants

4

Reactant 1

HCID 131710554Z-Thr(But)-Ser(But)-OMe

Product 1

HCID 131710555H-Thr(But)-Ser(But)-OMe

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

3.27 g of Z-Thr(But)-Ser(But)-OMe in 50 ml of ethyl acetate are hydrogenated in the presence of 0.5 g of palladium on charcoal (10% strength). After the absorption of hydrogen has ceased (1 hour), the catalyst is filtered off and the solution is evaporated. The product, which is obtained as an oil, is a single substance according to thin layer chromatography.

Workup

  1. customAfter the absorption of hydrogen
  2. custom(1 hour)
  3. filtrationthe catalyst is filtered off
  4. customthe solution is evaporated
  5. customThe product, which is obtained as an oil

Sources & evidence

ORD record
ord-8d1aeb1e520c44deaaf2c3e697668463
Source dataset
uspto-grants-1976_11
Patent number
US03994871

Reaction notes

Loading…