HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → Z-Ser(But)-Leu-OMe
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Isobutyl chloroformate | HCID 62365 | — |
| Reactant | Z-Ser(tBu)-OH | HCID 1715617 | — |
| Reactant | Leucine methyl ester hydrochloride | HCID 2723695 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Z-Ser(But)-Leu-OMe | HCID 13892395 | — |
Reaction Steps
2.75 ml of triethylamine and 2.63 ml of chloroformic acid isobutyl ester are added to 5.9 g of Z-Ser(But)-OH in 20 ml of ethyl acetate at -10°C. After 10 minutes, 4.0 g of H-Leu-OMe-HCl and 3.05 ml of triethylamine are added. After stirring for 11/2 hours in an ice bath, the mixture is extracted by shaking with phosphoric acid and sodium bicarbonate solution and after drying over sodium sulphate the ethyl acetate is evaporated completely. 8.2 g of a waxy mass are obtained. Melting point (after crystallisation from hexane): 56°-58°C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03994871 |
| Source dataset | uspto-grants-1976_11 |
| ORD ID | ord-43c49ebd5c3d43c8ab0b3df30a521619 |
| Source note | uspto-grants-1976_11 |