反应详情

2.75 ml of triethylamine and 2.63 ml of chloroformic acid isobutyl ester are added to 5.9 g of Z-Ser(But)-OH in 20 ml of ethyl acetate at -10°C. After 10 minutes, 4.0 g of H-Leu-OMe-HCl and 3.05 ml of triethylamine are added. After stirring for 11/2 hours in an ice bath, the mixture is extracted by shaking with phosphoric acid and sodium bicarbonate solution and after drying over sodium sulphate the ethyl acetate is evaporated completely. 8.2 g of a waxy mass are obtained. Melting point (after crystallisation from hexane): 56°-58°C.

1. extractionthe mixture is extracted
2. stirringby shaking with phosphoric acid and sodium bicarbonate solution
3. dry with materialafter drying over sodium sulphate the ethyl acetate
4. customis evaporated completely
5. custom8.2 g of a waxy mass are obtained
6. customMelting point (after crystallisation from hexane)
7. custom56°-58°C.