Hydrazine hydrate (1:1) → HCID 178454205, compound

Participants

Reaction Steps

27.9 g of Boc-Gln-His-OCH3 (Marchiori et al., J. Chem. Soc (C) 1967, 81) are dissolved in 280 ml of highest purity methanol, 28 ml of hydrazine hydrate are added and the mixture is left to stand for 20 hours at 25°C. It is concentrated to dryness in a high vacuum and the residue is recrystallised from methanol-ethyl acetate-petroleum ether. Melting point 187°-189°C.

Provenance & Evidence