Hydrazine hydrate (1:1) → HCID 178454205, compound

HRID 1731237Notes

Reaction equation

HRID 1731237 reaction equation
[NH:1]([C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])[C@H:2]([C:8]([NH:10][C@H:11]([C:18](OC)=[O:19])[CH2:12][C:13]1[N:17]=[CH:16][NH:15][CH:14]=1)=[O:9])[CH2:3][CH2:4][C:5](=[O:7])[NH2:6].O.[NH2:30][NH2:31]>CO>[NH:1]([C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])[C@H:2]([C:8]([NH:10][C@H:11]([C:18]([NH:30][NH2:31])=[O:19])[CH2:12][C:13]1[N:17]=[CH:16][NH:15][CH:14]=1)=[O:9])[CH2:3][CH2:4][C:5](=[O:7])[NH2:6]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 178501426HCID 178501426, compound

Product 1

HCID 178454205HCID 178454205, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

27.9 g of Boc-Gln-His-OCH3 (Marchiori et al., J. Chem. Soc (C) 1967, 81) are dissolved in 280 ml of highest purity methanol, 28 ml of hydrazine hydrate are added and the mixture is left to stand for 20 hours at 25°C. It is concentrated to dryness in a high vacuum and the residue is recrystallised from methanol-ethyl acetate-petroleum ether. Melting point 187°-189°C.

Workup

  1. additionare added
  2. waitthe mixture is left
  3. concentrationIt is concentrated to dryness in a high vacuum
  4. customthe residue is recrystallised from methanol-ethyl acetate-petroleum ether

Sources & evidence

ORD record
ord-46372493ce8f4f20b0f8cdb67fcde95d
Source dataset
uspto-grants-1976_11
Patent number
US03994871

Reaction notes

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