Hydrochloric Acid → HCID 53800200, compound

HRID 1731245Notes

Reaction equation

HRID 1731245 reaction equation
[F:1][C:2]([C:9]1[CH:13]=[CH:12][S:11][C:10]=1[S:14]([NH2:17])(=[O:16])=[O:15])=[C:3]([F:8])[C:4]([F:7])([F:6])[F:5].C1([O:24][C:25](=O)[NH:26][C:27]2[N:32]=[C:31]([O:33][CH3:34])[N:30]=[C:29]([O:35][CH3:36])[N:28]=2)C=CC=CC=1.O.Cl>C(#N)C>[CH3:34][O:33][C:31]1[N:30]=[C:29]([O:35][CH3:36])[N:28]=[C:27]([NH:26][C:25]([NH:17][S:14]([C:10]2[S:11][CH:12]=[CH:13][C:9]=2[C:2]([F:1])=[C:3]([F:8])[C:4]([F:7])([F:6])[F:5])(=[O:16])=[O:15])=[O:24])[N:32]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 11054937HCID 11054937, compoundHCID 54411206HCID 54411206, compound

Product 1

HCID 53800200HCID 53800200, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

According to steps (1) to (4) in Preparation Examples 1, 3-(1,2,3,3,3-pentafluoropropen-1-yl)-2-thiophenesulfonamide was prepared. A portion (0.3 g) of this substance and 0.311 g of phenyl-N-(4,6-dimethoxy-1,3,5-triazin-2-yl)carbamate were dissolved in 4 ml of dry acetonitrile. To the solution, 0.175 g of 1,8-diazabicyclo-(5,4,0)-7-undecene was added dropwise, and the mixture was subjected to reaction under stirring for 2.5 hours at room temperature. After completion of the reaction, the resulting product was poured into water and acidified with hydrochloric acid. The precipitated crystals were filtered, washed with water and dried to obtain 0.47 g of the object compound having a melting point of 149° to 153° C.

Workup

  1. customwas prepared
  2. customthe mixture was subjected to reaction
  3. customAfter completion of the reaction
  4. filtrationThe precipitated crystals were filtered
  5. washwashed with water
  6. customdried

Sources & evidence

ORD record
ord-eb8f701939e24eff80b1c308713b414d
Source dataset
uspto-grants-1986_11
Patent number
US04620868

Reaction notes

Loading…