Trifluoromethanesulfonic acid → HCID 54074415, compound

Participants

Reaction Steps

A portion (0.74 g) of the N-tert-butyl-3-(2-chloro-1,2-difluoroethenyl)-5-trimethylsilyl-2-thiophenesulfonamide prepared in (1) was treated with 4 ml of trifluoromethanesulfonic acid under stirring at room temperature for 2 hours. After completion of the reaction, the resulting product was poured into water and extracted with methylene chloride. The extracted layer was washed with water and dried. After distilling off methylene chloride under vacuum, the residual crystals were washed with a small amount of toluene and dried to obtain 0.26 g of 3-(2-chloro-1,2-difluoroethenyl)-2-thiophenesulfonamide having a melting point of 112° to 116° C.

Provenance & Evidence