Trifluoromethanesulfonic acid → HCID 54074415, compound

HRID 1731246Notes

Reaction equation

HRID 1731246 reaction equation
C([NH:5][S:6]([C:9]1[S:10][C:11]([Si](C)(C)C)=[CH:12][C:13]=1[C:14]([F:18])=[C:15]([Cl:17])[F:16])(=[O:8])=[O:7])(C)(C)C.FC(F)(F)S(O)(=O)=O>O>[Cl:17][C:15]([F:16])=[C:14]([C:13]1[CH:12]=[CH:11][S:10][C:9]=1[S:6]([NH2:5])(=[O:8])=[O:7])[F:18]

Participants

4

Reactant 2

HCID 62406Trifluoromethanesulfonic acidHCID 53901951HCID 53901951, compound

Product 1

HCID 54074415HCID 54074415, compoundYield 52.5%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A portion (0.74 g) of the N-tert-butyl-3-(2-chloro-1,2-difluoroethenyl)-5-trimethylsilyl-2-thiophenesulfonamide prepared in (1) was treated with 4 ml of trifluoromethanesulfonic acid under stirring at room temperature for 2 hours. After completion of the reaction, the resulting product was poured into water and extracted with methylene chloride. The extracted layer was washed with water and dried. After distilling off methylene chloride under vacuum, the residual crystals were washed with a small amount of toluene and dried to obtain 0.26 g of 3-(2-chloro-1,2-difluoroethenyl)-2-thiophenesulfonamide having a melting point of 112° to 116° C.

Workup

  1. customAfter completion of the reaction
  2. extractionextracted with methylene chloride
  3. washThe extracted layer was washed with water
  4. customdried
  5. distillationAfter distilling off methylene chloride under vacuum
  6. washthe residual crystals were washed with a small amount of toluene
  7. customdried

Sources & evidence

ORD record
ord-570e334749554b399440e9f0daf5e354
Source dataset
uspto-grants-1986_11
Patent number
US04620868

Reaction notes

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