Hydrochloric Acid → HCID 20228551, compound

HRID 1731287Notes

Reaction equation

HRID 1731287 reaction equation
C([C:4]1[C:5]([CH3:20])=[N:6][N:7]2[C:11]=1[N:10]([CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:9]([CH3:19])=[N:8]2)(=O)C.Cl>C(O)C>[CH2:12]([N:10]1[C:9]([CH3:19])=[N:8][N:7]2[N:6]=[C:5]([CH3:20])[CH:4]=[C:11]12)[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 20228553HCID 20228553, compound

Product 1

HCID 20228551HCID 20228551, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2 g of the 7-acetyl-1-benzyl-2,6-dimethylpyrazolo[1,5-b]-1,2,4-triazole thus-obtained was dissolved in 20 ml of ethanol, to the solution was added 20 ml of concentrated hydrochloric acid and the mixture was refluxed by heating. After about 6 hours, the ethanol was distilled off under reduced pressure, the reaction mixture was rendered alkaline with a saturated aqueous solution of sodium hydrogencarbonate and extracted with ethyl acetate to obtain 1.6 g (95% yield) of almost pure deacetylated compound, i.e., 1-benzyl-2,6-dimethylpyrazolo[1,5-b]-1,2,4-triazole.

Workup

  1. temperaturethe mixture was refluxed
  2. temperatureby heating
  3. distillationthe ethanol was distilled off under reduced pressure
  4. extractionextracted with ethyl acetate

Sources & evidence

ORD record
ord-e5a2f64c179d408ba691dc21883ada98
Source dataset
uspto-grants-1986_11
Patent number
US04621046

Reaction notes

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