Ammonia → HCID 70382541, compound

HRID 1731305Notes

Reaction equation

HRID 1731305 reaction equation
C(O[C:4](=[O:17])[CH2:5][N:6]1[CH2:10][C@@H:9]2C[CH2:12][CH2:13][CH2:14][CH2:15][C@@H:8]2[C:7]1=[O:16])C.[NH3:18]>CO>[O:16]=[C:7]1[C@H:8]2[C@@H:9]([CH2:12][CH2:13][CH2:14][CH2:15]2)[CH2:10][N:6]1[CH2:5][C:4]([NH2:18])=[O:17]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 131714941HCID 131714941, compound

Product 1

HCID 70382541HCID 70382541, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

For example, trans-octahydro-1-oxo-cyclohexa[c]pyrrole-2(1H)acetic acid ethyl ester (V) (6.6 g, 0.031 mole) in methanol is saturated with anhydrous ammonia and the mixture is stirred at room temperature 24 hours. The solution is concentrated at reduced pressure to yield a solid. Recrystallization from acetonitrile yields pure trans-octahydro-1-oxo-2H-isoindole-2-acetic acid amide (VI).

Workup

  1. concentrationThe solution is concentrated at reduced pressure
  2. customto yield a solid
  3. customRecrystallization from acetonitrile

Sources & evidence

ORD record
ord-0453b086ee9d476a9155df3bb3d88f61
Source dataset
uspto-grants-1986_11
Patent number
US04621097

Reaction notes

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