Ammonia → HCID 70382541, compound

Participants

Reaction Steps

For example, trans-octahydro-1-oxo-cyclohexa[c]pyrrole-2(1H)acetic acid ethyl ester (V) (6.6 g, 0.031 mole) in methanol is saturated with anhydrous ammonia and the mixture is stirred at room temperature 24 hours. The solution is concentrated at reduced pressure to yield a solid. Recrystallization from acetonitrile yields pure trans-octahydro-1-oxo-2H-isoindole-2-acetic acid amide (VI).

Provenance & Evidence