HCID 136332171, compound → HCID 135479969, compound

HRID 1731426Notes

Reaction equation

HRID 1731426 reaction equation
N#N.C([NH:6][C:7]1[NH:8][C:9](=[O:35])[C:10]2[N:11]=[CH:12][N:13]([CH2:16][O:17][CH:18]([CH2:27][O:28][C:29](=[O:34])[C:30]([CH3:33])([CH3:32])[CH3:31])[CH2:19][O:20][C:21](=[O:26])[C:22]([CH3:25])([CH3:24])[CH3:23])[C:14]=2[N:15]=1)(=O)C>[OH-].[NH4+].CO>[CH3:31][C:30]([CH3:33])([CH3:32])[C:29]([O:28][CH2:27][CH:18]([O:17][CH2:16][N:13]1[CH:12]=[N:11][C:10]2[C:9](=[O:35])[NH:8][C:7]([NH2:6])=[N:15][C:14]1=2)[CH2:19][O:20][C:21](=[O:26])[C:22]([CH3:23])([CH3:24])[CH3:25])=[O:34]

Participants

4

Reactant 1

HCID 136332171HCID 136332171, compound

Product 1

HCID 135479969HCID 135479969, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 14923Ammonium HydroxideSolvent

Procedure

A solution of N2 -acetyl-9-[1,3-di-(2,2-dimethylpropanoyloxy)-2-propoxymethyl]guanine in 10% ammonium hydroxide in methanol was kept at room temperature for 7 hours and then evaporated. The residue was recrystallized from methanol to give 9-[1,3-di-(2,2-dimethylpropanoyloxy)-2-propoxymethyl]guanine, m.p. 230°-232° C.

Workup

  1. customevaporated
  2. customThe residue was recrystallized from methanol

Sources & evidence

ORD record
ord-87b9443c8b83434ca8bd22bfa665f89f
Source dataset
uspto-grants-1986_11
Patent number
US04621140

Reaction notes

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