反应详情

温度

140 °C

3-Benzyloxy-2,2-dimethylpropionitrile (2.0 g, 10.6 mmol), potassium hydroxide (31.2 g, 86%, 479 mmol) and potassium carbonate (1.13 g, 82 mmol) were dissolved in methanol (340 ml), concentrated under reduced pressure. The resulting residue was heated at 140° C. (bath temperature) under nitrogen atmosphere, and stirred for 22 hours. The reaction mixture was dissolved in water, cooled in an ice-water bath, followed by controlling at pH of 1 with hydrochloric acid (36%) added thereto. The organic matter was extracted with diethyl ether, washed with saturated brine, dried on anhydrous magnesium sulfate, the solvent was evaporated away under reduced pressure to obtain the entitled compound (2.18 g, 99%) as a colorless solid.

1. concentrationconcentrated under reduced pressure
2. dissolutionThe reaction mixture was dissolved in water
3. temperaturecooled in an ice-water bath
4. additionadded
5. extractionThe organic matter was extracted with diethyl ether
6. washwashed with saturated brine
7. dry with materialdried on anhydrous magnesium sulfate
8. customthe solvent was evaporated away under reduced pressure