Hydrochloric Acid → HCID 20227708, compound

HRID 1731519Notes

Reaction equation

HRID 1731519 reaction equation
[ClH:1].C([O:10][CH2:11][CH:12]1[CH:15]2[C:16]3[C:21]([CH2:22][CH2:23][N:14]2[CH2:13]1)=[CH:20][C:19]([O:24][CH3:25])=[C:18]([O:26][CH3:27])[CH:17]=3)(=O)C1C=CC=CC=1.Cl>C(O)C>[ClH:1].[OH:10][CH2:11][CH:12]1[CH:15]2[C:16]3[C:21]([CH2:22][CH2:23][N:14]2[CH2:13]1)=[CH:20][C:19]([O:24][CH3:25])=[C:18]([O:26][CH3:27])[CH:17]=3

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 20227707HCID 20227707, compound

Product 1

HCID 20227708HCID 20227708, compoundYield 61%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

0.01 mole (3.22 g) of 1-(benzoyloxymethyl)-7,8-dimethoxy-1,4,5,9b-tetrahydro-2H-azeto[2,1-a]isoquinoline hydrochloride is boiled in a mixture of 50 ml of a 5% hydrochloric acid solution and 20 ml of ethanol for 2 hours. The mixture is evaporated and the evaporation residue is triturated with ether to yield the aimed compound with a melting point (after recrystallization from ethanol) of 219° to 221° C. (decomp.).

Workup

  1. customThe mixture is evaporated
  2. customthe evaporation residue is triturated with ether

Sources & evidence

ORD record
ord-79dfc166dbb84ce2a36270affa6b7478
Source dataset
uspto-grants-1986_11
Patent number
US04622327

Reaction notes

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