Triethylamine → HCID 13841669, compound

HRID 1731522Notes

Reaction equation

HRID 1731522 reaction equation
Cl.[Cl:2][CH2:3][CH:4]([CH2:21]Cl)[CH:5]1[C:14]2[C:9](=[CH:10][C:11]([O:18][CH2:19][CH3:20])=[C:12]([O:15][CH2:16][CH3:17])[CH:13]=2)[CH2:8][CH2:7][NH:6]1.C(N(CC)CC)C>C1C=CC=CC=1>[Cl:2][CH2:3][CH:4]1[CH:5]2[C:14]3[C:9]([CH2:8][CH2:7][N:6]2[CH2:21]1)=[CH:10][C:11]([O:18][CH2:19][CH3:20])=[C:12]([O:15][CH2:16][CH3:17])[CH:13]=3

Participants

4

Reactant 2

HCID 8471TriethylamineHCID 13841662HCID 13841662, compound

Product 1

HCID 13841669HCID 13841669, compoundYield 79%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

0.01 mole (3.69 g) of 1-[bis(chloromethyl)-methyl]-6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride is suspended in 50 ml of absolute benzene, and 5 ml of triethyl amine are added to the suspension. After standing for 2 hours the reaction mixture is evaporated to dryness. The residue is dissolved in water and extracted with three 50-ml portions of ether. The ethereal extract is dried and evaporated to yield the aimed compound as a crystalline residue. After recrystallization from ether the product melts at 91° to 93° C.

Workup

  1. customthe reaction mixture is evaporated to dryness
  2. dissolutionThe residue is dissolved in water
  3. extractionextracted with three 50-ml portions of ether
  4. extractionThe ethereal extract
  5. customis dried
  6. customevaporated

Sources & evidence

ORD record
ord-b1b81c66c25e41d8bb645e96562dfaf3
Source dataset
uspto-grants-1986_11
Patent number
US04622327

Reaction notes

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