4-Methoxybenzenesulfonyl chloride → HCID 70455624, compound

HRID 1731538Notes

Reaction equation

HRID 1731538 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([Cl:12])(=[O:11])=[O:10])=[CH:5][CH:4]=1.[NH2:13][CH2:14][CH2:15][CH2:16][N:17]1[CH2:21][CH2:20][CH2:19][CH2:18]1.S(Cl)(Cl)(=O)=O>[OH-].[Na+]>[Cl-:12].[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([NH:13][CH2:14][CH2:15][CH2:16][NH+:17]2[CH2:21][CH2:20][CH2:19][CH2:18]2)(=[O:11])=[O:10])=[CH:5][CH:4]=1

Participants

5

Reactant 3

HCID 74014-Methoxybenzenesulfonyl chlorideHCID 24648Sulfuryl chlorideHCID 316701-Pyrrolidinepropanamine

Product 1

HCID 70455624HCID 70455624, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

4-Methoxybenzenesulphonylchloride (8.26 g, 0.04 mol) was added in portions with stirring to a solution of 1-(3-aminopropyl)-pyrrolidine (5.13 g, 0.04 mol) in 10% NaOH (100 ml), and the resulting mixture was stirred at room temperature for the next 24 hours. Unreacted sulphonylchloride was filtered off, and the filtrate was adjusted to pH 9,8 with dilute HCl.

Workup

  1. filtrationwas filtered off

Sources & evidence

ORD record
ord-871e81b013334be1b1811329c14d3dc9
Source dataset
uspto-grants-1986_11
Patent number
US04622331

Reaction notes

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